Clinically Studied. Doctor Recommended.

Estrogen Support Probiotic

4.8 stars

Try the award-winning probiotic clinically shown to support estrogen levels in 12 weeks. Designed to help women in their 40s and 50s experiencing mood, sleep or weight changes due to hormonal shifts.

Clinically studied in two gold-standard trials
Third-party tested for purity & potency
Non-hormonal & safe for long-term use

Vegan

Gluten-Free

Non-GMO

No Added Hormones

Clinically-Backed

Third-Party Tested

Estrogen is a key hormone for women's health. Every single part of a woman's body depends on estrogen to operate at its best—including the brain, bones, heart, and muscles.

ALICIA JACKSON, Ph.D.
FDA ANNOUNCEMENT, NOVEMBER 2025

4.8 stars

Research has shown that the gut microbiome plays an essential role in women's hormonal health. Oval's Estrogen Support Probiotic boosts your body's natural hormone recycling power with clinically studied strains.

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Research has shown that the gut microbiome plays an essential role in women's hormonal health. Oval's Estrogen Support Probiotic boosts your body's natural hormone recycling power with clinically studied strains.

Slow down estrogen decline. Start now.

Supports

Slow down estrogen decline. Start your plan now.

  • 30-day money-back guarantee
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Benefits

Oval supports estrogen levels in 12 weeks. Benefits include:

+ Mental focus and clarity

+ Steady mood and energy

+ Deep and restful sleep

+ Vaginal health and comfort

+ Healthy weight and metabolism

+ Glowing skin and thicker hair

Who is Oval for?

Oval is for women navigating hormonal changes in their 30s, 40s, and 50s+ who want to feel more like themselves again. It supports key areas commonly affected by estrogen changes, including mood, focus, metabolism, sleep, skin, hair, and libido. It may also be a good option for women who are not using hormone therapy.

How does Oval work?

Oval supports a functional part of the gut microbiome called the estrobolome—the network of bacteria that helps recycle and regulate estrogen. By boosting this natural process, Oval helps maintain steadier estrogen levels while also supporting digestive and metabolic health.

How long does it take?

Hormone-related changes don’t happen overnight. Clinical studies showed results after 12 weeks of daily use, which is why we recommend giving your body a full three months to respond and settle into a new rhythm.

Recommended by Doctors

Dr. Kimberly Middleton

Dr. Kimberly Middleton

OB/GYN

The Oval Estrogen Support Probiotic can be an excellent choice for mood swings and brain fog related to perimenopause or menopause. The Oval Estrogen Support Probiotic can be an excellent choice for mood swings and brain fog related to perimenopause or menopause. Oval can target these brain-related issues by interacting with hormones in the gut. For example, estrogen can influence serotonin and acetylcholine, two brain chemicals tied to emotional balance and memory. Lactobacillus rhamnosus GG can help keep the gut lining strong, which may lower inflammation linked to changes in mood and brain function. Prebiotics like acacia fiber may also send calming signals to the brain by nurturing the growth and activity of helpful gut bacteria. Because it can contribute to so many different pathways, I feel confident in this supplement as a source of balance and support.
Dr. Mushmoom Khan

Dr. Mushmoom Khan

Family Medicine

For women who notice weight changes while in perimenopause or menopause, this supportive probiotic can be good for supporting estrogen and metabolic health. For women who notice weight changes while in perimenopause or menopause, this supportive probiotic can be good for supporting estrogen and metabolic health. Estrogen is a hormone that helps the muscles and liver respond to insulin, so the loss of estrogen can naturally influence weight-related processes, like blood sugar and fat storage. The probiotic strains in Oval can give support for those pathways and can help the body maintain metabolic balance. Another ingredient I want to highlight is acacia fiber. In this formula, acacia fiber acts as a prebiotic. It can feed beneficial microbes in the gut so they can produce fatty acids, which are involved in metabolic signaling. As a whole, I really like how this probiotic is made with ingredients that can give meaningful support for metabolism.
Dr. Annika Abrahamson

Dr. Annika Abrahamson

OB/GYN

A healthy estrogen metabolism can support skin hydration and may interact with the proteins responsible for maintaining the skin’s firmness. As estrogen decreases in perimenopause, some women may notice changes in skin texture and hair fullness. I am excited about this probiotic from Oval Daily because it can potentially influence hormone-related signals that are connected to collagen and follicle activity. Among the key actives are special bacteria that are part of the estrobolome, meaning they can help metabolize estrogen and keep it circulating through the body. A healthy estrogen metabolism can support skin hydration and may interact with the proteins responsible for maintaining the skin’s firmness. Acacia fiber has the potential to strengthen this effect with short-chain fatty acids that can contribute to normal skin-barrier function. These ingredients, plus others in this formula, can give women an easy way to care for the skin and scalp, help stabilize the gut lining, and support healthy immune balance.
Dr. Charmaine Gibson

Dr. Charmaine Gibson

OB/GYN

This probiotic blend can be a nice hormone-free option for digestive and vaginal comfort during middle-life hormonal shifts. This probiotic blend can be a nice hormone-free option for digestive and vaginal comfort during middle-life hormonal shifts. To help women with these issues, Oval Daily uses probiotics like Lactobacillus that can work to support a stable gut barrier. A healthy gut barrier can have a positive impact on the body by helping to reduce irritation and maintain immune balance. Research shows that certain Lactobacillus species may support the health of the vaginal microbiome. This is important for women to consider because their natural lactobacillus levels may decline as estrogen declines. Oval’s estrobolome strains may also interact with pathways linked to vaginal and urinary comfort. Overall, I am a big fan of this supplement for daily comfort and sexual wellness.
Dr. Janine Talty

Dr. Janine Talty

Family Medicine

I believe women in perimenopause may find this daily supplement can provide them with safe hormonal support and digestive comfort. I recommend this Estrogen Support Probiotic for women in perimenopause who are struggling with symptoms like hot flashes, sleep changes, or brain fog. It uses three probiotics strains designed to support estrogen balance in the gut, which may encourage the body to naturally recycle some of its own estrogen. In a large study, similar probiotics were shown to help women maintain healthier estrogen levels and improve well-being. One specific probiotic, Lactobacillus rhamnosus GG, can support the gut lining and may help patients feel more comfortable through hormonal changes. I believe women in perimenopause may find this daily supplement can provide them with safe hormonal support and digestive comfort.
Dr. Nina Sweeney

Dr. Nina Sweeney

Family Medicine

I appreciate Oval’s Estrogen Support Probiotic because it uses probiotics that can help promote more balanced estrogen activity. Estrogen is a very important hormone in the body that can play essential roles in bone strength, vessel function, and brain signaling. I appreciate Oval’s Estrogen Support Probiotic because it uses probiotics that can help promote more balanced estrogen activity. Estrobolome strains, for example, can influence estrogen metabolism in the intestines, which is connected in research to natural hormone recycling. Because it can influence estrogen metabolism, I see Oval offering potential support for women in their 40s and 50s. Beyond estrogen activity, this blend can indirectly influence other areas of health as well, including the bones, brain, and cardiovascular system. I’m glad to see a women’s supplement that can provide natural support for all these different processes.
Dr. Srilatha Reddy

Dr. Srilatha Reddy

Family Medicine

These probiotics can help slow down age-related estrogen loss. I like how this multi-strain probiotic from Oval Daily can support women’s digestion. It’s common for women to get constipated or experience irregular digestion as they approach menopause. This digestive discomfort is partly caused by changes in estrogen within the body, which can influence the activity of muscles in the gut. These probiotics can help slow down age-related estrogen loss and may keep more estrogen active in the gut, supporting more regular bowel movements. Lactobacillus rhamnosus GG (another probiotic strain) can add even more support by strengthening the gut lining and aiding regularity. I like the addition of acacia fiber as well, since it can feed bacteria in the gut and encourage smoother movement of stool through the bowel. One study linked gum acacia with increases in gut bacteria tied to healthy digestive function.
Dr. Ingrid Hoden

Dr. Ingrid Hoden

Family Medicine

When estrogen is more available, it can do a better job of supporting cardiovascular processes like vessel flexibility and cholesterol balance. Estrogen normally helps keep blood vessels flexible and supports healthy cholesterol levels. Before or during menopause, the amount of estrogen in the body can vary, so it’s smart to have a daily supplement like Oval that can give consistent support. It uses clinically studied strains of bacteria that can encourage natural hormone recycling and may slow down the typical rate of estrogen loss. When estrogen is more available, it can do a better job of supporting cardiovascular processes like vessel flexibility and cholesterol balance. For more heart support, Oval includes other probiotics that can help the gut make metabolites, which are linked to healthier vessels and smoother blood flow. Supporting the gut barrier may also reduce low-grade inflammation that can affect the heart and vessels over time.
Dr. Wilhelmina Azu

Dr. Wilhelmina Azu

OB/GYN

This can support steadier estrogen activity and may also indirectly influence temperature and sleep regulation. Many middle-aged women experience nighttime episodes of overheating or sudden wakefulness, which is why I want to recommend this probiotic supplement. Menopause can cause estrogen levels to decrease, a change that can affect multiple bodily systems and may lead to sleep interruptions and temperature changes. I like this supplement because it works within the gut to help recycle and reabsorb estrogen. This can not only support steadier estrogen activity but may also indirectly influence temperature and sleep regulation. In clinical trials, women taking similar supplements experienced improvements in both sleep-related problems and hot flashes. I’m optimistic about this probiotic for female patients, especially those who want to support their physical comfort overnight.
Dr. Craig Petry

Dr. Craig Petry

Family Medicine

This microbiome-based approach can support estrogen activity and may help a lot of women maintain stronger bones as they age. I love that this probiotic supplement considers the importance of bone health in premenopausal women. At this phase of life, women may not realize their bones may be getting weaker. Bone density often shifts because of decreases in estrogen, which influences how calcium is incorporated into bone tissue. This supplement can work through critical gut-hormone pathways, and may help keep estrogen more active inside the body, thereby supporting the cells that build and maintain bones. All this matters for patients because thinner, more porous bones are prone to fractures, which can greatly affect mobility and independence. In my opinion, this microbiome-based approach can support estrogen activity and may help a lot of women maintain stronger bones as they age.
Verified byfrontrowMD

How We Compare

Traditional Supplements
Hormone Therapy
Supports Estrogen Levels
Proven Symptom Relief
Clinically Studied Results
Doctor Recommended
Third-Party Tested
Non-Hormonal

Benefits of Healthy Estrogen Levels

Estrogen regulates insulin sensitivity and fat distribution, helping to reduce midsection weight gain and improve metabolism.

By boosting collagen and follicle health, estrogen keeps skin firm and glowing while promoting thicker, shinier hair.

Estrogen fuels neurotransmitters that improve memory, reduce brain fog and increase control over mood swings.

Estrogen helps regulate your internal clock and stabilize nighttime temperature, supporting deeper, more restorative sleep.

Estrogen supports vaginal tissue health and natural lubrication, supporting comfort and sex drive through midlife.

Estrogen maintains bone density and supports healthy joints, reducing the risk of osteoporosis and improving mobility as you age.

Estrogen maintains healthy cholestrerol ratios and blood vessel elasticity, promoting cardiovascular function.

Feel Like Yourself Again

4.8 stars

My midsection feels less puffy and my digestion finally feels regular again.

– Tanya R, 51

My cravings aren’t running the show anymore. I feel more in control.

– Melissa K, 48

I feel lighter and more balanced overall, like my body’s working with me again.

– Daphne W, 43

I fall asleep easier and stay asleep more consistently—it’s a huge relief.

– Paige M, 44

I just feel calmer in the evenings, not wired like before.

– Hannah B, 48

My sleep feels deeper and I wake up more centered.

– Jade F, 52

The brain fog lifted. I feel clearer and more myself again.

– Lauren E, 51

My mood feels steadier, not up and down all day.

– Kelly A, 48

I’m more focused and organized, even during stressful weeks.

– Clara H, 42

No more afternoon crash—my energy actually lasts.

– Erin H, 55

My energy feels clean and steady, not jittery.

– Monica R, 43

I finally have the motivation to move my body again.

– Talia F, 45

My skin feels more hydrated and calm than it has in years.

– Rachel S, 49

People keep commenting on my glow—especially when I’m not wearing makeup.

– Nora D, 55

My complexion looks smoother and more even-toned.

– Jo B, 42

More comfort, less dryness, and I feel more like myself again.

– Tess M, 45

I’m reconnecting with my body in a way I wasn’t expecting.

– Anna D, 43

Intimacy feels easier and more natural now.

– Lara V, 56

How Oval Works

How Oval Works

1.

Produces a natural enzyme

Probiotic strains in Oval make beta-glucuronidase, which helps unlock estrogen stored in your gut.

2.

Sustains estrogen levels

Once unlocked, this estrogen can be naturally reused by your body to sustain healthy levels.

3.

Feel like yourself again

Estrogen supports the systems that make you feel like you—your mood, energy, and confidence.

Formulated by PhD Scientists. Tested in Two Gold-Standard Trials.

  • Two Gold-Standard Trials

    Two 12-week randomized, double-blind, placebo-controlled trials

  • Who Was Tested

    Trial 1: 113 women ages 45 to 55

    Trial 2: 210 women ages 45 to 60

  • What They Took

    One capsule of Oval's Estrobolome Complex™ each day for 90 days

  • The Results

    62% higher estrogen levels than placebo after 12 weeks
What is a gold-standard clinical trial?

A gold-standard clinical trial is a randomized, double-blind, placebo-controlled study—the most rigorous way to test whether a product truly works. Participants are randomly assigned to receive either the active product or a placebo, and neither they nor the researchers know who gets which until the study ends. This design eliminates bias and ensures reliable, scientific results.

About Us

Our mission is to help women navigate the hormonal changes of midlife with confidence and clarity.

Estrogen influences so much of how you feel—from your energy, mood, and focus to your sleep, skin, hair, libido, and weight. Yet when estrogen begins to decline, many women are left without clear guidance or reliable support.

That’s why we created the Estrogen Support Probiotic—a science-backed supplement designed to ease the physical and emotional ups and downs of perimenopause and menopause by supporting estrogen naturally.

We’re committed to products that are grounded in clinical research, transparent in how they work, and focused on real physiological benefits, not vague promises or trends.

What matters most to us is helping you feel more confident, more in control, and more like you every day.

FAQs

Why Oval?

Oval is a daily probiotic designed to support your body’s own estrogen balance during perimenopause and menopause. Rather than adding hormones, it works through the gut microbiome to help your body maintain natural hormonal stability—supporting mood, metabolism, skin, hair, sex, sleep, and long-term health.

What Are The Benefits?

Oval supports steady estrogen levels. Benefits of maintaining estrogen as you age include:

Clearer Mind & Steadier Mood: Supports memory, focus, and emotional balance

Healthier Weight: Supports a leaner, more comfortable body and helps prevent midsection weight gain

Glowing Skin: Promotes firmer, smoother, more radiant skin

Thicker, Shinier Hair: Supports fuller, healthier-looking hair

Restful Sleep: Supports deeper sleep and stable nighttime temperature

Sexual Wellness: Increases comfort, natural lubrication, and sex drive

Stronger Bones & Heart: Supports long-term bone and cardiovascular health

Who is it for?

Oval is for women navigating hormonal changes in their 30s, 40s, and 50s+ who want to feel more like themselves again. It supports key areas commonly affected by estrogen changes, including mood, focus, metabolism, sleep, skin, hair, and libido. It may also be a good option for women who are not using hormone therapy.

Does it contain hormones?

No. Oval’s Estrogen Support Probiotic is completely non-hormonal. It doesn’t contain estrogen or alter your hormone production—it supports your body’s natural ability to recycle and balance its own estrogen.

Can I take it with hormone therapy (HRT/MHT)?

Yes. Oval is safe to take alongside HRT/MHT and can complement it. Many women use Oval before, during, or after hormone therapy to support gut health and healthy estrogen metabolism.

Is it safe to take every day?

Yes. Oval’s probiotic strains are clinically studied, well-tolerated, and safe for long-term daily use. Because it’s non-hormonal and microbiome-based, it supports both hormonal and digestive health naturally.

How Long Does It Take?

Hormone-related changes don’t happen overnight. Clinical studies showed results after 12 weeks of daily use, which is why we recommend giving your body a full three months to respond and settle into a new rhythm.

How does Oval work?

Oval supports a part of the gut microbiome called the estrobolome, the community of bacteria that help regulate and recycle estrogen. By restoring this natural process, Oval helps maintain steadier estrogen levels and smoother hormonal transitions while also supporting digestion, metabolism, and overall well-being.

What is the estrobolome?

The estrobolome (pronounced ESS-tro-bo-lome) is the group of gut bacteria that help regulate how estrogen is processed in the body. These bacteria produce enzymes that reactivate estrogen so it can be reabsorbed and reused instead of being lost. When the estrobolome becomes less active, as often happens during perimenopause and menopause, more estrogen is excreted, contributing to symptoms like hot flashes, mood changes, and fatigue. Supporting a healthy estrobolome helps your body maintain a more balanced hormonal environment naturally.

What is beta-glucuronidase?

Beta-glucuronidase (pronounced BAY-tuh gloo-kyoor-ON-ih-dase) is an enzyme made by certain gut bacteria that helps reactivate estrogen in the body. When estrogen is processed by the liver, it is often bound for excretion; beta-glucuronidase releases that bound estrogen, allowing it to be reabsorbed and recirculated naturally. This recycling process is one of the estrobolome’s key roles in maintaining hormonal balance.

Is Oval clinically studied?

Yes. The probiotic strains in Oval’s formula have been evaluated in two randomized, double-blind, placebo-controlled clinical trials with more than 300 women. Women taking the probiotic blend maintained healthier estrogen levels and experienced improvements in hot flashes, sleep, fatigue, and mood after 12 weeks of daily use.

Is it possible to quantify the effect of estrogen recycling?

Yes, indirectly. Researchers measure how efficiently the body recycles estrogen by looking at changes in circulating hormone levels, especially estradiol (E2), after interventions that influence the gut microbiome. In clinical studies, women taking Oval’s probiotic blend maintained 62% higher estradiol levels compared with placebo after 12 weeks, suggesting measurable support for natural estrogen recycling.

When will I start to feel a difference?

Every woman’s body is different, but many begin noticing changes, like better sleep, improved mood, or increased comfort, within 6 to 8 weeks. In clinical studies, measurable benefits were seen after 12 weeks of consistent use.

How do I take it?

Take one capsule daily with food or as part of your morning routine. The key is consistency—it works best when you take it every day.

What are the ingredients?

Each Capsule contains:

Oval Estrobolome Complex™ – a proprietary blend of three clinically studied probiotic strains (Lactiplantibacillus plantarum KABP051, Levilactobacillus brevis KABP052, and Pediococcus acidilactici KABP021) shown to support natural estrogen recycling and counter the symptoms of estrogen decline

Lactobacillus rhamnosus GG – a well-researched probiotic strain for women's health that reinforces gut-barrier integrity, reduces inflammation, and supports vaginal microbiome balance

Organic Acacia Fiber – a gentle prebiotic that nourishes beneficial gut bacteria and helps maintain microbiome stability

All ingredients are non-GMO, gluten-free, and suitable for daily use.

What makes Oval different?

Most menopause supplements focus on symptom relief using herbs or plant estrogens. Oval is rooted in microbiome science—it helps your body support its own estrogen naturally through the gut–hormone connection. It’s a smarter, more effective, and sustainable way to promote balance from within.

Can I take Oval with another probiotic?

You can, but it’s usually not needed. Oval’s formulation is comprehensive and specifically designed to target both gut and hormonal health at once.